Top 10 Funniest Guests Ever on Jimmy Kimmel Live!

Over the years, Jimmy Kimmel Live! has hosted countless celebrities, but only a handful delivered truly unforgettable comedy moments. These guests stood out for their quick wit, outrageous stories, and perfect comedic timing that sent the audience into laughter. Some appearances went completely off-script, turning simple interviews into viral late-night classics. Whether through self-mocking humor or unexpected chaos, these guests brought out the best in Jimmy Kimmel. Fans still revisit these segments for nonstop laughs. Together, they represent the funniest guest appearances in the show’s history.