Methods to compare the dissolution profile
Oct 23, 2022
4.There are several methods to compare the dissolution profile. Details are summarized in given as follows:
1. Visual process of comparison (Graphs)
2. Statistical analysis
-t-test
-Analysis-of-variance (ANOVA)
3. Model-dependent-methods
-Zero order
-First order
-Hixson Crowell cube root law
-Takeru Higuchi model
-Weibull model
-Korsemeyar and peppas model
4. Model-independent-methods
-Ratio Test Procedure
-Pair Wise Procedure/ Difference factor (f1) and Similarity factor (f2)
-Multivariate Confidence Regi0n Procedure
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