(CME) Serotonin Syndrome, NMS, and Stevens-Johnson syndrome (SJS): Dr Shyamashish Gupta
Feb 4, 2026
Serotonin syndrome is a serious reaction to certain medications that can lead to dangerously high levels of serotonin in the body. Serotonin is a naturally occurring chemical that our bodies produce, and it plays a crucial role in how our nerve cells and brain operate. However, when there's an excess of serotonin, it can trigger a range of symptoms, from mild issues like shivering and diarrhea to more severe problems such as muscle rigidity, fever, and seizures. If left untreated, severe serotonin syndrome can even be fatal.
Neuroleptic Malignant Syndrome (NMS) is another serious condition that can arise from taking antipsychotic medications, which are often prescribed for psychiatric disorders like schizophrenia and bipolar disorder. It can also happen if someone suddenly stops taking dopamine agonists, which are used to manage conditions like Parkinson's disease.
Then there's Stevens-Johnson syndrome (SJS), a rare but serious skin and mucous membrane disorder. This condition typically starts with flu-like symptoms and progresses to a painful rash that spreads and blisters. Eventually, the top layer of the affected skin dies, sheds, and begins to heal over several days. SJS is considered a medical emergency and usually requires hospitalization. Treatment focuses on identifying and removing the cause, caring for the wounds, managing pain, and minimizing complications as the skin heals. Recovery can take anywhere from weeks to months.
(CME) Serotonin Syndrome, NMS, and Stevens-Johnson syndrome (SJS): Dr Shyamashish Gupta
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