Video thumbnail for Slay the Spire 2: 10 Essential Multiplayer Tips

Slay the Spire 2: 10 Essential Multiplayer Tips

Mar 12, 2026
IGN Logo

IGN

Verified Open.Video Creator Badge
Slay the Spire 2 ups the difficulty compared to the first game, and playing with friends brings out some of the most challenging battles to take on. With more players, there's more variation in each run – not to mention the scaled HP for all Elites and Bosses in each act! But, there are ways to set your group up for success with a bit of planning and communication. If you're looking to squad up, don't miss out on these 10 essential multiplayer tips for Slay the Spire 2.0:00 - Intro0:37 - How to Set Up Multiplayer1:00 - Build a Balanced Party2:48 - Slow Down and Coordinate Plays3:50 - Debuffs Benefit Everyone4:37 - Choose Relics That Match Your Build5:15 - Pick Up Multiplayer-Specific Cards5:48 - Throw Potions on Your Teammates6:36 - Build Synergies Across the Team7:27 - Have a Designated Survivor8:13 - Choose Your Map Path Wisely9:08 - Play More to Unlock Stronger Items9:55 - OutroFor more Slay the Spire 2 tips and tricks, check out our Wiki guide at https://www.ign.com/wikis/slay-the-spire-2
#Computer & Video Games