0:01
For a large part of the 20th century,
0:03
many scientists believed that human
0:05
evolution had basically hit the pause
0:06
button. The assumption was that because
0:09
we invented modern medicine, built warm
0:12
houses, and learned to purify our water,
0:14
we had insulated ourselves from the
0:16
harsh forces of nature. Since we could
0:18
just use technology to survive, the
0:20
thinking went, our bodies no longer
0:22
needed to adapt. However, modern
0:25
genetics has completely busted this
0:27
myth. Not only are humans still
0:29
evolving, but in many ways, our rate of
0:31
genetic adaptation has actually sped up
0:33
over the last 10,000 years. Instead of
0:36
stopping evolution, our modern world has
0:38
just shifted the pressures that drive
0:39
it. We currently live in the
0:41
anthroposine, an era defined by the
0:43
massive impact humans have had on the
0:45
earth. By farming, building cities, and
0:48
changing everything from the atmosphere
0:50
to global ecosystems, we have
0:52
drastically altered the world around us.
0:54
This leads to something scientists call
0:56
gene culture co-evolution.
0:59
Basically, our cultural habits and
1:01
technologies create brand new
1:02
environments. Living in packed cities,
1:05
eating processed foods, and moving into
1:08
extreme climates introduce new physical
1:10
stresses. In response, our bodies are
1:13
forced to adapt genetically to survive
1:15
in the very world we built. When we
1:17
think of evolution, we usually picture
1:20
massive changes taking millions of
1:21
years. But micro evolution, smaller
1:24
anatomical shifts, is happening right
1:26
now, observable over just a few
1:31
The case of the extra artery, one of the
1:33
most mind-blowing examples of modern
1:35
human evolution, is happening right in
1:37
our forearms. When a human fetus is
1:40
developing in the womb, it grows a
1:41
median artery to supply blood to the
1:43
hands and arms. Historically, this
1:46
artery was temporary. It usually
1:48
disappeared entirely by the 8th week of
1:49
pregnancy, making way for other
1:51
permanent blood vessels. For most of
1:53
human history, adults simply didn't have
1:55
this artery, but that is changing
1:59
Back in the 1880s, only about 10% of
2:02
adults kept this extra artery. By the
2:04
late 1900s, that number had surged to
2:07
over 30%. And today, scientists estimate
2:10
that roughly 35% of the global
2:13
population retains it into adulthood.
2:15
This is a massive anatomical shift
2:17
happening in the blink of an
2:18
evolutionary eye. If this trend
2:20
continues, projections suggest that
2:23
anyone born 80 years from now will have
2:25
this extra artery. Infectious diseases
2:27
act as one of the most ruthless and
2:29
rapid drivers of human evolution.
2:31
Pathogens like viruses and bacteria
2:34
interact directly with our DNA, forcing
2:37
our bodies to adapt or die. Because
2:39
diseases can so easily bypass the
2:42
medicines and shelters we build, our
2:44
immune systems are essentially heavily
2:45
scarred battlegrounds, constantly molded
2:48
by past epidemics. To see how fast a
2:51
disease can change human genetics,
2:53
evolutionary biologists look at the
2:55
black death. In the mid-4th century, the
2:58
bubonic plague swept across Europe,
3:00
Asia, and North Africa, wiping out up to
3:03
60% of the European population in just 5
3:06
This catastrophic loss of life forced a
3:09
massive rapid burst of evolution in the
3:11
human immune system. Recently,
3:13
scientists extracted ancient DNA from
3:15
the remains of people who lived before,
3:17
during, and after the plague. They
3:20
discovered something incredible, a
3:22
specific genetic variant related to the
3:24
ERA2 gene. This gene essentially acts
3:28
like an alarm system, helping the body
3:30
chop up invading pathogens and present
3:32
them to the immune system for a massive
3:36
People who carried two copies of this
3:37
protective gene variant were 40% more
3:39
likely to survive the black death.
3:42
Naturally, these survivors lived to pass
3:44
this highly advantageous trait onto
3:46
their children, permanently altering the
3:48
DNA of their descendants. In evolution,
3:50
there is rarely a free lunch. Scientists
3:53
call this antagonistic pleotropy, a
3:56
complex term that simply means a gene
3:58
that saves your life in one environment
4:00
might harm you in another. That
4:01
hypervigilant er2 gene variant was a
4:04
superpower against the medieval plague.
4:07
But today, without the black death to
4:09
fight, that same hyperactive immune
4:11
response is a major risk factor for
4:13
autoimmune disorders like Crohn's
4:15
disease. In these conditions, the immune
4:17
system gets confused and aggressively
4:19
attacks healthy tissue. In a very real
4:21
way, the modern rise in autoimmune
4:23
diseases is a biological echo of our
4:26
ancestors surviving medieval pandemics.
4:28
Viruses and parasites have left a
4:30
massive permanent footprint on human
4:32
genetics. In fact, out of the 25,000
4:35
total genes in the human body, over
4:38
4,000 interact directly with pathogens
4:40
since our ancestors split from other
4:42
great apes. About a third of all our
4:44
evolutionary protein changes have been
4:46
driven specifically by the need to fight
4:49
off viral infections. You can see this
4:51
ancient evolutionary arms race in how we
4:53
resist modern diseases today. For
4:56
example, certain genetic mutations that
4:58
successfully protect people from malaria
5:00
also carry a high biological cost, such
5:03
as causing cickle cell anemia.
5:06
Another fascinating example is a
5:08
specific genetic mutation found
5:09
predominantly in European populations
5:12
that provides strong natural resistance
5:16
Because HIV is a relatively new human
5:18
disease, scientists believe this
5:20
mutation actually evolved about 2,000
5:22
years ago to fight off much older
5:24
plagues like smallpox or historical
5:26
hemorrhagic fevers. Today, that ancient
5:29
genetic armor just happens to block HIV
5:31
from entering our cells perfectly. The
5:34
recent CO 19 pandemic gave scientists a
5:37
real-time look at how our ancient
5:38
genetics interact with brand new
5:40
viruses. The specific cellular receptors
5:43
that the CO 19 virus uses to invade our
5:46
bodies have been heavily protected by
5:47
evolution for thousands of years.
5:49
Meaning they were absolutely crucial for
5:51
our underlying survival long before this
5:54
specific pandemic emerged. But why did
5:56
some people get so much sicker from CO
5:58
19 than others? Aside from age and
6:01
pre-existing conditions, part of the
6:03
answer lies with our extinct ancestors.
6:06
When modern humans migrated out of
6:08
Africa roughly 50,000 years ago, they
6:11
interbred with Neanderthalss and
6:12
Denisven who had already been living in
6:14
Eurasia for hundreds of thousands of
6:16
years. These archaic humans had already
6:19
spent millennia adapting to local
6:21
European and Asian viruses. When we
6:23
interbred with them, we inherited
6:25
fragments of their immune boosting DNA.
6:28
Today, specific genetic variants
6:30
inherited from those ancient encounters
6:32
from 50,000 years ago directly influence
6:35
how susceptible a modern person is to
6:38
severe respiratory infections like COVID
6:42
By inventing farming and altering our
6:44
diets, we actually forced our own DNA to
6:46
adapt. The domestication of animals and
6:49
the planting of starchy crops caused
6:51
massive genetic mutations to sweep
6:53
through human populations. As a direct
6:56
result, modern humans evolved the
6:58
lifelong ability to digest milk, lactase
7:00
persistence, and naturally produce up to
7:02
eight times more starch digesting
7:04
enzymes in our saliva than our closest
7:07
primate relatives. Our anatomy has
7:10
completely re-engineered itself to
7:11
support our intense need to communicate
7:13
and share ideas. Our voice boxes dropped
7:16
to create a vocal resonating chamber,
7:19
even though it wildly increased our risk
7:21
of choking. Our mouths shortened for
7:23
acrobatic tongue movement. And our
7:25
skulls literally change shape to fit the
7:27
massive nerve bundles required for
7:29
talking. Our minds and morals are also
7:32
the result of intense evolutionary
7:33
engineering. Because ancient survival
7:36
required strict teamwork, evolution
7:38
hardwired our brains to be pro-social.
7:41
Complex social emotions like guilt,
7:43
shame, and pride aren't just abstract
7:46
concepts. They're biological alarm bells
7:49
physically built into specific areas of
7:51
our brain tissue, designed to enforce
7:53
rules, encourage fairness, and keep our
7:56
communities functioning smoothly. As
7:58
ancient humans migrated out of Africa
8:00
and spread across the globe, they
8:02
encountered extreme environments that
8:04
pushed their bodies to the absolute
8:05
limit. One of the greatest survival
8:08
challenges was high altitude hypoxia,
8:11
the dangerous lack of oxygen at extreme
8:13
elevations. If an unadjusted person
8:15
climbs above 11,000 ft, they face
8:18
life-threatening conditions like acute
8:20
mountain sickness and dangerously
8:22
thickened blood as their body panics and
8:24
overproduces red blood cells. Yet
8:27
indigenous populations living in the
8:29
Tibetan plateau, the Andian Aliplano,
8:32
and the Ethiopian highlands thrive in
8:34
these zones. This is a textbook example
8:37
of convergent evolution, a phenomenon
8:39
where completely disconnected groups of
8:41
people face the exact same environmental
8:44
threat, but evolve completely different
8:46
genetic ways to survive it. The Tibetan
8:49
Highlanders adapted to thin mountain air
8:51
by evolving the ability to keep their
8:53
red blood cell counts incredibly low,
8:55
protecting their hearts from thickened
8:57
blood while naturally breathing much
8:59
faster to take in more oxygen.
9:02
Amazingly, scientists discovered that
9:04
the specific gene allowing Tibetans to
9:06
do this was inherited from an ancient
9:08
extinct human cousin called the
9:12
On the other side of the world, Andian
9:14
Highlanders evolved the exact opposite
9:16
physical strategy. Their bodies adapted
9:19
to elevated altitudes by naturally
9:20
pumping up their hemoglobin levels to
9:23
carry more oxygen per drop of blood, and
9:25
they actually breathe slower than
9:26
average. Meanwhile, high altitude
9:29
populations in Ethiopia present a third
9:31
highly unique biological solution.
9:34
Despite living miles above sea level,
9:36
Ethiopian highlanders maintain the exact
9:38
same blood oxygen levels as someone
9:41
living on the beach in California.
9:43
Natural selection targeted the same
9:45
oxygen sensing network in all three
9:47
populations, but mutated completely
9:49
different genes to get the job done.
9:52
When we look at how modern medicine
9:53
impacts evolution, one of the most
9:56
dramatic changes happening right now
9:57
involves human childbirth. Human child
10:00
birth is notoriously difficult and
10:02
dangerous compared to that of other
10:03
animals. This is due to an evolutionary
10:05
catch 22 known as the obstetric dilemma.
10:09
Millions of years ago, our ancestors
10:11
started walking upright on two legs
10:13
which required our pelvis to become
10:15
narrow and rigid. But much later, our
10:18
brains rapidly expanded, meaning babies
10:20
were born with massive skulls. For
10:23
millennia, this tight fit was ruthlessly
10:25
controlled by natural selection. Mothers
10:28
with overly narrow hips or babies with
10:30
excessively large heads simply did not
10:33
survive childirth. This grim reality
10:36
acted as a biological ceiling,
10:38
physically stopping human heads from
10:40
getting any bigger. However, the
10:42
widespread use of the scissor section
10:44
over the last 60 years has completely
10:46
bypassed this evolutionary limit. By
10:48
using surgery, modern medicine allows
10:51
genes for larger heads and narrower hips
10:53
to be safely passed on to the next
10:55
generation. Because of this,
10:57
mathematical models estimate that the
10:59
biological rate of babies simply being
11:01
too big to fit through the birth canal
11:03
has jumped by up to 20% in just a few
11:06
generations. This is a massive,
11:08
incredibly rapid shift in human anatomy
11:11
driven entirely by surgical technology.
11:14
Our ability to cure diseases has
11:16
completely changed the human gene pool.
11:18
Historically, genetic conditions were
11:20
eliminated from the gene pool because
11:22
people who had them did not survive to
11:24
have children. Today, life-saving
11:26
treatments like insulin for type 1
11:28
diabetes allow people to survive,
11:31
thrive, and pass those genes on. While
11:33
this is an absolute moral and medical
11:35
victory, from a purely evolutionary
11:37
standpoint, it means the human species
11:39
is becoming increasingly reliant on
11:41
external medicine to survive. Finally,
11:44
evolutionary biologists point out that
11:45
many of our modern health crises like
11:48
the epidemics of obesity and type 2
11:50
diabetes [music] are actually mismatched
11:52
diseases. For hundreds of thousands of
11:54
years, the human metabolism evolved to
11:57
survive starvation and intense physical
11:59
labor. Today we live highly stressed,
12:01
sedentary lives surrounded by incredibly
12:03
calorie dense processed foods. Our
12:06
ancient bodies are simply struggling to
12:08
process the modern world we built for
12:09
ourselves. It is a very popular science
12:12
fiction trope that as global travel
12:14
increases and cultures mix, humanity
12:16
will eventually blend into one uniform
12:19
identical looking global population. But
12:22
genetics paints a much more complex and
12:24
fascinating picture. While it is true
12:26
that urban hubs in places like the
12:28
Americas and Western Europe are seeing
12:30
massive genetic mixing, global migration
12:32
is not an even worldwide blender.
12:36
Massive population centers like India
12:38
and China actually experience very low
12:40
rates of inward migration compared to
12:42
their enormous total sizes. Because
12:45
these incredibly deep genetic pools
12:47
remain highly stable, they act as a
12:49
massive mathematical barrier against
12:51
total global blending. Instead of
12:54
erasing our differences, modern
12:56
globalization is actually creating a
12:58
profound era of diversification.
13:00
As formerly isolated populations meet in
13:03
globalized hubs, they reproduce and
13:05
create entirely new, never-beforeseen
13:08
combinations of genes. Rather than
13:11
turning humanity into a single genetic
13:13
monolith, our highly connected world is
13:15
expanding our genetic diversity, giving
13:18
our species more biological tools to
13:20
survive whatever the future throws at
13:23
For millions of years, human evolution
13:25
was essentially a cosmic lottery driven
13:27
by random mutations and the unforgiving
13:29
rules of survival of the fittest. But as
13:32
we dive deeper into the 21st century,
13:34
that is all changing because humanity is
13:36
about to take the steering wheel. Thanks
13:39
to a groundbreaking technology called
13:40
Crisper, which acts like a microscopic
13:43
cut and paste tool for our genes,
13:45
scientists can now edit DNA inside
13:47
living cells. Right now, this technology
13:50
is mostly used to treat sick patients.
13:52
But the future points to something much
13:54
bigger, which is editing the
13:55
foundational DNA of embryos. Once this
13:58
becomes safe and accepted, we will
14:00
literally be able to rewrite our own
14:02
evolutionary code, erasing inherited
14:04
genetic diseases before a child is even
14:06
born, or eventually boosting our
14:08
physical and mental traits to turn human
14:11
biology into a programmable canvas.
14:14
While gene editing will change how we
14:16
live on Earth, our biggest evolutionary
14:18
leap will likely happen in the
14:19
unforgiving void of space. As we gear up
14:22
to build colonies on the moon and Mars,
14:24
our bodies will face extreme
14:26
environments we were never built to
14:27
survive, like bonewasting microgravity
14:30
and DNA damaging cosmic radiation. To
14:33
survive off world, we will have to adapt
14:35
incredibly fast. And scientists believe
14:37
that living in isolated space colonies
14:39
could force us to evolve so quickly that
14:42
humans born in deep space might become
14:44
an entirely new subspecies. We will also
14:46
likely need to merge with our technology
14:49
relying on cybernetic implants,
14:51
synthetic radiation resistant skin, or
14:53
genetically tweaked metabolisms just to
14:55
survive. Down the line, space dwelling
14:58
humans might naturally develop wider
15:00
nostrils to handle different
15:01
atmospheres, larger eyes to see on dimly
15:04
lit planets, and smaller muscles since
15:06
robots will be doing all the heavy
15:08
lifting. If you think humans have
15:10
stopped evolving, the modern evidence
15:12
proves otherwise. As our bodies are
15:14
actively adapting to modern life right
15:15
now, instead of evolving to outrun
15:18
predators, we are adapting to modern
15:20
viruses, highly processed food, and the
15:22
artificial worlds we've built.
15:24
Ultimately, our evolution is permanently
15:25
tied to our technology and culture. And
15:28
for the first time in history, we are no
15:30
longer waiting for nature to decide our
15:32
fate, but are instead using advanced
15:34
tools to dictate our own biological
15:36
destiny among the stars.